New publication

Congratulations to Hafna and the rest of the FDOR team, whose paper “Sequence-structure-function classification of a catalytically diverse oxidoreductase superfamily in mycobacteria” has been published in JMB.

This reclassification, functional annotation and structural analysis of flavin/deazaflavin oxidoreductases (FDORs) shows the varied functions of FDORs in mycobacteria and provides a framework to understand their role in mycobacterial pathogenesis and persistence.

hafna_jmb abstract

New publication

Congratulations to Eleanor, who published a paper entitled “Reverse evolution leads to genotypic incompatibility despite functional and active site convergence” in eLife, together with our incredible collaborator Nobuhiko Tokuriki at the University of British Columbia.

This paper shows that the evolution of a enzyme in vitro can be reversed by reversing the selection pressure, but not by reversing the substitutions originally responsible for the change in function. This shows how epistasis can make evolution phenotypically reversible, but genotypically irreversible.

In the media: breakthrough in blowfly resistance research

From ABC Rural:

Australian researchers say a study on insecticide resistance in flies could save the sheep industry millions of dollars.

Flies can become resistant to insecticides called organophosphates, making it harder for farmers to treat flystrike, where flies lay eggs in the sheep’s skin leading to a lingering and painful death if left untreated.

(Read more)

 

Image by Sally Bryant