Catching up on some new & old news

The last year or so has been a big one in the Jackson lab! We have had several PhD students submit and head off of new adventures; we have welcomed new members to group; had a number of exciting papers published, and attended conferences together. However, the blog section of this page has been aContinue reading “Catching up on some new & old news”

New publication

Congratulations to Nansook, who published a paper in Biochemistry together with collaborators from the Tokuriki lab: “Conformational tinkering drives evolution of a promiscuous activity through indirect mutational effects”. [link] In this work, we used laboratory evolution to effect a thousand-fold increase in phosphotriesterase activity in a lactonase enzyme. Mutations acquired during evolution altered the position ofContinue reading “New publication”

New Publication

Congratulations to Peter, whose paper “Sensing and signaling of oxidative stress in chloroplasts by inactivation of the SAL1 phosphoadenosine phosphatase” was published in PNAS [link]. This work was done with a number of collaborators, including the Pogson group at the ANU Research School of Biology. When adverse conditions like drought cause oxidative stress in plant chloroplasts, a chemical messenger originating from theContinue reading “New Publication”

New publication

Congratulations to Hafna, Elaaf and Brendon, whose paper “Rv2074 is a novel F420H2-dependent biliverdin reductase in Mycobacterium tuberculosis” was published in Protein Science. [link] In this work, we identified and characterised a biliverdin reductase from Mycobacterium tuberculosis, and elucidated its catalytic mechanism. This enzyme produces a potent antioxidant, bilirubin, using biliverdin, which is produced inContinue reading “New publication”

New publication

Congratulations to Galen and the E3 team whose paper “Mapping the accessible conformational landscape of an insect carboxylesterase using conformational ensemble analysis and kinetic crystallography” has been published in Structure. Using automated multi-conformer modelling and ensemble refinement, we uncovered a dynamically coupled network important for catalysis in an organophosphate-degrading enzyme, and using kinetic crystallography, weContinue reading “New publication”

New publication

Congratulations to Chris, Hafna, Elaaf and Brendon, whose review “Physiology, biochemistry, and applications of F420- and Fo-dependent redox reactions” was published in Microbiology and Molecular Biology Reviews. The cover highlights some of the proteins that depend on the unique deazaflavin cofactor F420.