We have recently welcomed a new PhD student, Kang, to the Jackson Lab. Kang has recently arrived in Canberra after travelling from South Korea. Kang did his previous studies at Seoul National University, and has worked at the Korea Institute of Science and Technology. We look forward to sharing the lab with Kang!
Colin, Peter and Joe attended the 2016 ComBio Conference in Brisbane. Colin and Peter both gave talks on some of the exciting work being done in the group. Joe also won a poster prize for his poster ‘From binding protein to enzyme’. Well done Joe, what a champion!
The last year or so has been a big one in the Jackson lab! We have had several PhD students submit and head off of new adventures; we have welcomed new members to group; had a number of exciting papers published, and attended conferences together. However, the blog section of this page has been aContinue reading “Catching up on some new & old news”
Congratulations to Drs Dongdi Li, Hafna Ahmed and William Zhang on their recent graduation.
Congratulations to Nansook, who published a paper in Biochemistry together with collaborators from the Tokuriki lab: “Conformational tinkering drives evolution of a promiscuous activity through indirect mutational effects”. [link] In this work, we used laboratory evolution to effect a thousand-fold increase in phosphotriesterase activity in a lactonase enzyme. Mutations acquired during evolution altered the position ofContinue reading “New publication”
Congratulations to Peter, whose paper “Sensing and signaling of oxidative stress in chloroplasts by inactivation of the SAL1 phosphoadenosine phosphatase” was published in PNAS [link]. This work was done with a number of collaborators, including the Pogson group at the ANU Research School of Biology. When adverse conditions like drought cause oxidative stress in plant chloroplasts, a chemical messenger originating from theContinue reading “New Publication”
Congratulations to Hafna, Elaaf and Brendon, whose paper “Rv2074 is a novel F420H2-dependent biliverdin reductase in Mycobacterium tuberculosis” was published in Protein Science. [link] In this work, we identified and characterised a biliverdin reductase from Mycobacterium tuberculosis, and elucidated its catalytic mechanism. This enzyme produces a potent antioxidant, bilirubin, using biliverdin, which is produced inContinue reading “New publication”
Catching up on some old lab news: William Zhang, Dongdi Li, Nansook Hong and Elaaf Mohamed have all recently submitted their PhD theses. Congratulations everyone! We also welcome Jules Kirk to the lab as an Honours student.
Congratulations to Galen and the E3 team whose paper “Mapping the accessible conformational landscape of an insect carboxylesterase using conformational ensemble analysis and kinetic crystallography” has been published in Structure. Using automated multi-conformer modelling and ensemble refinement, we uncovered a dynamically coupled network important for catalysis in an organophosphate-degrading enzyme, and using kinetic crystallography, weContinue reading “New publication”
Congratulations to Chris, Hafna, Elaaf and Brendon, whose review “Physiology, biochemistry, and applications of F420- and Fo-dependent redox reactions” was published in Microbiology and Molecular Biology Reviews. The cover highlights some of the proteins that depend on the unique deazaflavin cofactor F420.