“Laboratory evolution of protein conformational dynamics” – new review paper

Check out our latest review on the laboratory evolution of protein conformational dynamics, published in Current Opinion in Structural Biology. This review focuses on recent work that has begun to establish specific functional roles for protein conformational dynamics, specifically how the conformational landscapes that proteins can sample can evolve under laboratory-based evolutionary selection. We discuss recent technical advances in computational and biophysical chemistry, which have provided us with new ways to dissect evolutionary processes. Finally, we offer some perspectives on the emerging view of conformational dynamics and evolution, and the challenges that we face in rationally engineering conformational dynamics.

ConfDynamics Review Figure

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