New Publication

Colin, Thanavit, Blair and Brendon contributed to the recently published paper entitled “Mycobacterial F420H2-dependent reductases promiscuously reduce diverse compounds through a common mechanism” in Frontiers in Microbiology. This work presents the first broad survey of actinobacterial F420H2-dependent reductases as potential industrial biocatalysts by exploring the extent, as well as mechanistic and structural bases, of their substrate promiscuity. The findings of this work suggest that engineered actinobacterial F420H2-dependent reductases are promising novel biocatalysts for the facile transformation of a wide range of α,β-unsaturated compounds. Top work guys!

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