New publication

Congratulations to Peter, Galen and Nick, whose paper “Conformational disorganization within the active site of a recently evolved organophosphate hydrolase limits its catalytic efficiency” was published in Biochemistry.

In this paper, we characterised a gain-of-function substitution in an enzyme, which provides resistance to organophosphate pesticides in the Australian sheep blowfly. The full catalytic potential of this substitution is not realised because of frequent sampling of conformational states that are unproductive for catalysis. This may be a common feature of recently-evolved enzymes.


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